Sex hormone–binding globulin (SHBG) is a protein made mainly in the liver. It binds strongly to key sex hormones like testosterone, dihydrotestosterone (DHT), and estradiol. By doing so, SHBG controls how much of these hormones stay “free” (unbound) and biologically active in the body. Think of SHBG as a gatekeeper: it influences how much hormone is available to tissues in both men and women.
SHBG
The Specter of Estrogen Dominance
Estrogen dominance permeates the discussion of hormone therapy and balance, it is not a medical term. Dr. John Lee first introduced the idea of estrogen dominance. It didn’t matter if estrogen levels were too high or normal or even too low. If progesterone was low relative to the estrogen effect, then one could suffer from … Read more