Cardio NAD+

NAD3® + Niacinamide:

The first ingredient selected is NAD3®, a new and novel ingredient which uses a different approach to manage cardiovascular factors while having positive influences on the hallmarks of aging.  NAD3® is a unique blend of Wasabi japonica extract, theacrine and copper(I)-niacin complex. It turbocharges enzymes that boost the conversion of NAD+ precursors to NAD+ while also suppressing the activity proteins that deplete NAD+. This product has been designed to help modulate inflammation and reduce lipids in our blood associated with heart disease. Compared to placebo, at a dose of 312mg daily, NAD3® lead to significant changes in multiple cardiovascular risk factors (-19%VLDL, -16%LDL, -12%Tot Chol) with a safe, well-tolerated dietary supplement that also demonstrated multiple additional benefits related to healthy aging and cellular longevity.  NAD3® may improve NAD+ status by supporting its synthesis and limiting its degradation, in addition to activating the downstream signaling pathways of longevity, while minimizing the chronic stress of aging.

NAD3® slows down biological aging by playing both “offense” (amplifying the stress-resilience/ longevity genes), and “defense” (by mitigating the molecular and biochemical hallmarks of aging).  A recent published study demonstrated NAD3® can positively alter molecular markers related to lipid metabolism, cardiometabolic health and hallmarks of aging. NAD3® is a multi-mechanistic solution for healthy aging, mitochondrial performance, cellular longevity.

In addition, we have added 200mg’s of niacinamide per serving. A single dose of 200 mg niacinamide has been shown to be sufficient to target NAD+ salvage and other metabolic pathways to affect blood metabolites.These findings demonstrate the feasibility of niacinamide supplementation to modulate metabolic pathways in humans, especially since niacinamide has been studied as a dietary supplement for decades and excellent safety data on long-term use are already available.

PeptiPump™ Peptide Complex:

Healthgevity has also partnered with Nuritas to harness their proprietary technology, which evaluates millions of plant proteins. This innovative approach sifts through vast molecular data to forecast natural plant bioactive peptides, identifying which have the most Angiotensin-converting enzyme inhibition (ACEi) activity. Leveraging state-of-the-art AI-driven precision technology, Nuritas uncovered groundbreaking peptides known as PeptiPump™. Derived from lentil protein hydrolysate, PeptiPump™ boasts a network of patented bioactive peptides, meticulously designed to withstand gastrointestinal digestion. Studies have demonstrated that ACE inhibition not only enhances muscle oxygenation but also promotes improved blood flow within skeletal muscles.

Coenzyme Q10 (CoQ10):

CoQ10 is renowned for its myriad health benefits, encompassing support for heart health, cognitive function, and muscular vitality. Its potent antioxidative properties combat oxidative stress, enhance energy production, and contribute to supporting healthy blood pressure and cholesterol levels. By shielding cells from oxidative damage, CoQ10 holds promise in mitigating the risk of chronic ailments. Crucially, CoQ10 plays a pivotal role in cellular energy production, rendering it a compelling natural remedy for combatting fatigue and muscle weakness. Cardio NAD+ features a novel ingredient newly introduced to the US market, featuring CoQ10 enhanced by LEO-HB® technology. This eco-friendly, cutting-edge solid-solid technology transforms poorly soluble, bioactive ingredients with limited bioavailability into highly efficient, free-flowing powders. These powders seamlessly disperse in cold water, ensuring rapid solubility and superior performance.

Fucoidan:

Mekabu extract, sourced from Undaria pinnatifida, commonly known as wakame, is specifically derived from the sporophyll, the reproductive structure of this brown seaweed. This extract is standardized to contain approximately 85% fucoidan, a complex carbohydrate abundantly present in various brown seaweeds.

Fucoidan has garnered considerable attention in the realm of nutrition and health, particularly for its potential cardiovascular benefits. The glycocalyx, a layer of intricate carbohydrates enveloping endothelial cells along blood vessel walls, plays a pivotal role in vascular function. Dysfunction or damage to the glycocalyx is closely linked to cardiovascular diseases like atherosclerosis and hypertension.

Research indicates that fucoidan exhibits remarkable properties in glycocalyx regeneration. By fostering the repair and rejuvenation of the glycocalyx, fucoidan aids in preserving endothelial integrity and functionality. Consequently, this supports enhanced vascular health and potentially mitigates the risk of cardiovascular complications.

FitNox®:

FitNox® is a cutting-edge formulation featuring three potent botanical extracts (moringa, pomegranate and black ginger) meticulously chosen to amplify vasodilation and endurance by naturally boosting nitric oxide (NO) levels within the body, without relying on nitrates. Harnessing the power of Polar-Nonpolar-Sandwich (PNS) technology, these botanical components are encapsulated within a protective plant-based matrix for optimal delivery.

Scientific studies have demonstrated that FitNox® significantly elevates nitric oxide (NO) levels by up to 336%, facilitating enhanced vasodilation and blood flow. It targets various components involved in NO production, thereby supporting improved endurance while counteracting factors that induce fatigue and limit performance.

Moreover, short-term supplementation with FitNox® yields rapid and sustained increases in Nitrate and Nitrite levels, with effects manifesting within just one hour and lasting up to ten hours. This swift and enduring response underscores its capacity to promptly elevate nitric oxide levels, fostering improved pump and blood flow for enhanced performance.

A long term (22 day) study was performed to investigate the efficacy of oral intake of 250 mg of FitNox® on physical endurance in healthy male adults before and after exercise. Measurements were taken in regard to nitrate and nitrite (PK), Lactate dehydrogenase (LDH), Malondialdehyde (MDA), dopamine and exercise efficiency.

Nattokinase:

We’ve meticulously crafted ingredient combinations to address critical facets of heart health, including blood pressure regulation and blood viscosity management. Cardio NAD+ features nattokinase, renowned for its ability to promote healthy inflammation levels, mitigate clot formation, and optimize blood pressure, supported by extensive research spanning numerous years.

Derived from soybeans, this natural ingredient has demonstrated remarkable efficacy, with studies showcasing a reduction in systolic blood pressure by 13.55 points in just four weeks. In vitro experiments and human trials further highlight nattokinase’s potential to enhance blood flow, decrease blood viscosity, diminish red blood cell stickiness, and inhibit platelet aggregation.

Bergamot:

Citrus Bergamot, an aromatic fruit from southern Italy, has also been added to the formula.  ​ Bergamot’s remarkable properties have been extensively studied, revealing its ability to positively impact various cardio-metabolic biomarkers, including cholesterol, triglycerides, LDL, and HDL.

This unique blend of natural ingredients offers unparalleled supportive protection against one of the leading global causes of mortality. By fortifying lipid profiles, optimizing blood pressure, and addressing systemic inflammation, this formulation enhances cardiovascular mechanics and offers multifaceted benefits for overall heart health and well-being.