Hormones

Fascinating “Human Hibernation” Theory That Finally Explains Why We’re So Sick – And How to Turn It Off

I just finished THE WINTER GENE: The Cause of Most Modern Diseases and How to Turn It Off by Jeff T. Bowles, and it’s one of the most thought-provoking health books I’ve read in years. If you’re tired of treating symptoms with pill after pill and want a big-picture explanation for obesity, heart disease, cancer, … Read more

Follow-Up: Progesterone, Weight, Appetite, and Energy Balance — Nuanced Insights from Dr. Jerilynn Prior

Progesterone increases appetite without weight gain during the luteal phase

A few days after publishing my piece on progesterone and weight gain, I received a thoughtful email from Dr. Jerilynn C. Prior, MD, FRCPC, Professor Emerita of Medicine and a leading researcher in women’s reproductive health and menstrual cycle science. She kindly gave me permission to share her comments here.

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What Is Sex Hormone–Binding Globulin (SHBG)?

SHBG-mechanism-of-action

Sex hormone–binding globulin (SHBG) is a protein made mainly in the liver. It binds strongly to key sex hormones like testosterone, dihydrotestosterone (DHT), and estradiol. By doing so, SHBG controls how much of these hormones stay “free” (unbound) and biologically active in the body. Think of SHBG as a gatekeeper: it influences how much hormone is available to tissues in both men and women.

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Women and the Crisis in Sex Hormones

“Women and the Crisis in Sex Hormones” by Barbara Seaman is a bold 1987 critique of synthetic hormone therapies, including the birth control pill and menopause treatments, exposing their risks and the medical industry’s profit-driven oversights. Book Overview Seaman warns of dangers like blood clots, strokes, heart attacks, and cancers from high-dose estrogens, urging women … Read more

5β-Reductase (AKR1D1): Hormone Off-Switch & Digestion Hero

A middle aged woman in front of a table of healthy fruits and vegetables, off to the right is a illustration of a liver and a diagram explaining how it interacts with five beta reductase

Imagine your hormones as messengers racing through your body, delivering important signals. But what happens when they stick around too long? Enter 5β-reductase, a hardworking liver enzyme that acts like a gentle “off-switch,” calming down hormones like progesterone, testosterone, and cortisol while powering up the bile that helps you digest fats. This unsung hero keeps your hormone levels balanced and your digestion smooth—yet most people have never heard of it.[journals.plos]​

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