Resistance Is Futile? Endometriosis and the Progesterone Resistance Standoff

A young woman with brunette colored hair a white shirt and blue jeans having a headache and pelvic pains.

Endometriosis is a chronic condition affecting millions of women worldwide, characterized by the growth of uterine-like tissue outside the uterus. One of its key underlying issues is progesterone resistance, a state where the body’s tissues fail to respond adequately to progesterone—a hormone essential for regulating the uterine lining’s growth. This article explores the mechanisms behind progesterone resistance, its interplay with estrogen receptors, environmental factors, and emerging treatment strategies.

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Introduction to Progesterone in Men

middle aged man with gynecomastia

This article is an introduction to understanding the role of progesterone in men. Progesterone is often associated with women’s health, particularly in relation to pregnancy and menstrual cycles. However, it also plays a crucial role in men’s health. This hormone is a precursor to testosterone, the primary male sex hormone, and helps maintain hormonal balance … Read more

The Specter of Estrogen Dominance

Estrogen Dominance

Estrogen dominance permeates the discussion of hormone therapy and balance, it is not a medical term. Dr. John Lee first introduced the idea of estrogen dominance. It didn’t matter if estrogen levels were too high or normal or even too low. If progesterone was low relative to the estrogen effect, then one could suffer from … Read more

Can You Use TOO Much Progesterone?

Too much progesterone

Too much progesterone, how much is too much? During the last trimester of pregnancy, women can reach levels of progesterone in the serum as high as 200-300 ng/ml and more. During the luteal phase, getting to a level of 20 to 30 ng/ml is usual. Most women feel amazing during the last three months of … Read more

PMDD: The Tragedy of Premenstrual Dysphoric Disorder

PMDD

PMDD treatment frequently fails to address the underlying need for progesterone. This article reviews how restoring progesterone has fallen off the radar. A few weeks ago, I received this email from Gemma Banks who hosts a Facebook group in the UK. (1) Hi Carol, Firstly, I’d like to say ‘Thank-you’ for everything you do and … Read more