The Specter of Estrogen Dominance

Estrogen Dominance

Estrogen dominance permeates the discussion of hormone therapy and balance, it is not a medical term. Dr. John Lee first introduced the idea of estrogen dominance. It didn’t matter if estrogen levels were too high or normal or even too low. If progesterone was low relative to the estrogen effect, then one could suffer from … Read more

Can You Use TOO Much Progesterone?

Too much progesterone

Too much progesterone, how much is too much? During the last trimester of pregnancy, women can reach levels of progesterone in the serum as high as 200-300 ng/ml and more. During the luteal phase, getting to a level of 20 to 30 ng/ml is usual. Most women feel amazing during the last three months of … Read more

PMDD: The Tragedy of Premenstrual Dysphoric Disorder


PMDD treatment frequently fails to address the underlying need for progesterone. This article reviews how restoring progesterone has fallen off the radar. A few weeks ago, I received this email from Gemma Banks who hosts a Facebook group in the UK. (1) Hi Carol, Firstly, I’d like to say ‘Thank-you’ for everything you do and … Read more

Progesterone and the mTOR Aging System

person holding a stress ball

Unraveling how and why we age is a research focus.  We are still captivated by the Ponce de Leon promise of the Fountain of Youth.  An enzyme system named mTOR (mammalian or mechanistic target of rapamycin) was identified in mouse studies as a significant aging mechanism.  Inhibition of mTOR by rapamycin, found in bacteria species: S. cerevisiae, C. elegans, … Read more

The Tyranny of Flow Chart Medicine

crop doctor with stethoscope in hospital

When I started my career as a pharmacist many years ago, one of my mentors warned me that pharmacists were expendable. We would soon be replaced by vending machines. Indeed, I witnessed the first of these being installed in hospitals to dispense commonly used drugs on the floors. Medical practitioners are equally expendable. With FDA … Read more