Hormone therapy for pain management is a topic not well documented. In this article, we’ll attempt to fill in those gaps. Hormones are powerful chemical messengers in the body, influencing everything from mood to metabolism. One of their lesser-known but critical roles is in pain management. By modulating pain perception, inflammation, and stress responses, hormones can significantly impact how we experience and cope with pain. This article explores the key hormones involved in pain management, their mechanisms, and emerging therapies like oxytocin and hormone replacement therapy (HRT) that offer hope for more effective, sustainable pain relief.